@article{barghout2026igloo,
  title = {Do protein representations encode variant function? Diagnosing residue-level protein attributions via embedding-space gradients},
  author = {Barghout, Rana A. and Wu, Shengqing and Chau, William and Barraza-Chavez, José Manuel and Driza, Paola and Mahadevan, Radhakrishnan and Sanchez-Lengeling, Benjamin},
  journal = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.21.760763},
  url = {https://doi.org/10.64898/2026.10.21.760763},
  preprint = {https://www.biorxiv.org/content/10.64898/2026.10.21.760763v1},
  github = {https://github.com/chemcognition-lab/IGLOO},
  keywords = {proteins, xai, ai},
  abstract = {Introduces IGLOO, a diagnostic framework that evaluates whether residue-level embedding gradients from protein language models faithfully capture functional importance against synthetic and experimental fitness landscapes.},
}